I can't think of anything else to try except maybe making sure DMA is on, reinstalling the driver, or disabling/enabling the drive. If those things don't work, you've either got a terrible virus I don't know about (highly unlikely) or your DVD drive has failed. They're pretty cheap unless you go lite scribe (which you probably don't need). $30 at walmart should get you up and running again. If you don't know how to replace a DVD drive, just take the computer case off and it's really self explanatory. Just unscrew the existing one, take out the 3 cords in the back of it, slide it out the front, slide the new one in from the front, reconnect the cables, and then screw the new one in. The computer will automatically recognize it. That's all you have to do.