In the Spidar-Man 2 video game, Quinten Beck tries to shoot Spider-Man with a laser but it breaks.
Spider-Man: What's the matter, Beck? Something wrong with your laser? They have pills for that now, you know.
Seriously, I can't believe Spider-Man said that!
I mean, do you get what he was saying?
Later on, Mysterio tells Spider-Man to come to his hidden fortress so they can fight.
Spider-Man: Gee, Mysterio's "hidden fortress" looks just like... an appartement!
(Moments later, he finds a hiden passage behind a book shelf)
Spider-Man: (sarcasm) Wow! A hidden door concealed by book case? Mysterio, you brilliant fiend!
Here is the scene I am refering to on Youtube.
http://www.youtube.com/watch?v=sdWuYaeF7OU&feature=relatedSpider-Man: Hey Mysterio, does your Mother Ship know you're here?
The Mysterio part of the game had the best jokes.
http://www.youtube.com/watch?v=Y7WEE35S2Mg&feature=related