Simba would win because his roar could scare the little guy away.
HEY! I didn't say Simba, I said TIMON, y'know, the meerkat who always hangs on with Pumbaa from the Lion King!
Well, anyway. Jafar will use his hypnotic staff against Ganondorf, using him to serve his evil purposes.
How about Donkey Kong VS. Knuckles?